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Mechanosensitive Rap1 activation promotes barrier function of lung vascular endothelium under cyclic stretch
Mechanical ventilation remains an imperative treatment for the patients with acute respiratory distress syndrome, but can also exacerbate lung injury. We have previously described a key role of RhoA GTPase in high cyclic stretch (CS)–induced endothelial cell (EC) barrier dysfunction. However, cellul...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589902/ https://www.ncbi.nlm.nih.gov/pubmed/30759056 http://dx.doi.org/10.1091/mbc.E18-07-0422 |