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Synthetic and Crystallographic Insight into Exploiting sp(2) Hybridization in the Development of α‐l‐Fucosidase Inhibitors

The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, α‐l‐fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel α‐l‐fucosidase inhibitors, with X‐ray crystallograph...

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Detalles Bibliográficos
Autores principales: Coyle, Travis, Wu, Liang, Debowski, Aleksandra W., Davies, Gideon J., Stubbs, Keith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589914/
https://www.ncbi.nlm.nih.gov/pubmed/30663832
http://dx.doi.org/10.1002/cbic.201800710