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Synthetic and Crystallographic Insight into Exploiting sp(2) Hybridization in the Development of α‐l‐Fucosidase Inhibitors
The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, α‐l‐fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel α‐l‐fucosidase inhibitors, with X‐ray crystallograph...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589914/ https://www.ncbi.nlm.nih.gov/pubmed/30663832 http://dx.doi.org/10.1002/cbic.201800710 |