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A Comprehensive Review of Pegvaliase, an Enzyme Substitution Therapy for the Treatment of Phenylketonuria

OBJECTIVE: To review the pharmacology, pharmacokinetics, efficacy, safety, and place in therapy of a phenylalanine-metabolizing enzyme indicated to reduce blood phenylalanine concentrations, pegvaliase injection. DATA SOURCES: Searches of MEDLINE (1946-September 1, 2018) were conducted using the ter...

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Detalles Bibliográficos
Autores principales: Hydery, Tasmina, Coppenrath, Valerie Azzopardi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589953/
https://www.ncbi.nlm.nih.gov/pubmed/31258325
http://dx.doi.org/10.1177/1177392819857089