The development and prevalidation of an in vitro mutagenicity assay based on MutaMouse primary hepatocytes, Part I: Isolation, structural, genetic, and biochemical characterization

To develop an improved in vitro mammalian cell gene mutation assay, it is imperative to address the known deficiencies associated with existing assays. Primary hepatocytes isolated from the MutaMouse are ideal for an in vitro gene mutation assay due to their metabolic competence, their “normal” kary...

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Detalles Bibliográficos
Autores principales: Cox, Julie A., Zwart, Edwin P., Luijten, Mirjam, White, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590113/
https://www.ncbi.nlm.nih.gov/pubmed/30592088
http://dx.doi.org/10.1002/em.22253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590113/
https://www.ncbi.nlm.nih.gov/pubmed/30592088
http://dx.doi.org/10.1002/em.22253

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