Synthesis of (11)C‐labeled ubiquinone and ubiquinol via Pd(0)‐mediated rapid C‐[(11)C]methylation using [(11)C]methyl iodide and 39‐demethyl‐39‐(pinacolboryl)ubiquinone

To enable positron emission tomography (PET) imaging of the in vivo kinetics of ubiquinone and ubiquinol, which is referred to as coenzyme Q(10), their (11)C‐radiolabeled counterparts were synthesized herein. (11)C‐Labeled ubiquinone [(11)C]‐1 was realized by Pd‐mediated rapid C‐[(11)C]methylation o...

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Detalles Bibliográficos
Autores principales: Goto, Miki, Nishiyama, Akira, Yamaguchi, Takao, Watanabe, Kyosuke, Fujii, Kenji, Watanabe, Yasuyoshi, Doi, Hisashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590163/
https://www.ncbi.nlm.nih.gov/pubmed/30556149
http://dx.doi.org/10.1002/jlcr.3700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590163/
https://www.ncbi.nlm.nih.gov/pubmed/30556149
http://dx.doi.org/10.1002/jlcr.3700

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