Development of a liver‐specific Tet‐off AAV8 vector for improved safety of insulin gene therapy for diabetes

BACKGROUND: Diabetes mellitus is caused by a partial or complete lack of insulin production in the body. We have previously shown that a single injection of an adeno‐associated virus serotype 8 (AAV8) vector carrying a modified and codon optimized human insulin gene induced hepatic production of ins...

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Detalles Bibliográficos
Autores principales: Gan, Shu Uin, Fu, Zhenying, Sia, Kian Chuan, Kon, Oi Lian, Calne, Roy, Lee, Kok Onn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590178/
https://www.ncbi.nlm.nih.gov/pubmed/30592790
http://dx.doi.org/10.1002/jgm.3067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590178/
https://www.ncbi.nlm.nih.gov/pubmed/30592790
http://dx.doi.org/10.1002/jgm.3067

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