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Development of a liver‐specific Tet‐off AAV8 vector for improved safety of insulin gene therapy for diabetes
BACKGROUND: Diabetes mellitus is caused by a partial or complete lack of insulin production in the body. We have previously shown that a single injection of an adeno‐associated virus serotype 8 (AAV8) vector carrying a modified and codon optimized human insulin gene induced hepatic production of ins...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590178/ https://www.ncbi.nlm.nih.gov/pubmed/30592790 http://dx.doi.org/10.1002/jgm.3067 |