Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human

Receptor occupancy (RO) is a translational biomarker for assessing drug efficacy and safety. We aimed to apply a physiologically based pharmacokinetic (PBPK) modeling approach to predict the brain dopamine D2 RO time profiles of antipsychotics. Clozapine and risperidone were modeled together with th...

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Detalles Bibliográficos
Autores principales: Wong, Yin Cheong, Centanni, Maddalena, de Lange, Elizabeth C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Physiologically Based Pharmacokinetic Modeling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590357/
https://www.ncbi.nlm.nih.gov/pubmed/30676661
http://dx.doi.org/10.1002/jcph.1365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590357/
https://www.ncbi.nlm.nih.gov/pubmed/30676661
http://dx.doi.org/10.1002/jcph.1365

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