TMF inhibits miR-29a/Wnt/β-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes

Background: miR-29a, a downstream factor of Wnt/β-catenin signaling, promotes the activity of the Wnt/β-catenin signaling in a positive feedback loop. Our previous work showed that 5,7,3ʹ,4ʹ-tetramethoxyflavone (TMF), a major constituent from Murraya exotica L., exhibited chondroprotective activity...

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Detalles Bibliográficos
Autores principales: Huang, Xianhua, Chen, Zhixi, Shi, Weimei, Zhang, Rui, Li, Linfu, Liu, Hai, Wu, Longhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590397/
https://www.ncbi.nlm.nih.gov/pubmed/31354246
http://dx.doi.org/10.2147/DDDT.S209694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590397/
https://www.ncbi.nlm.nih.gov/pubmed/31354246
http://dx.doi.org/10.2147/DDDT.S209694

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