Cargando…

Glioblastoma endothelium drives bevacizumab‐induced infiltrative growth via modulation of PLXDC1

Bevacizumab, a VEGF‐targeting monoclonal antibody, may trigger an infiltrative growth pattern in glioblastoma. We investigated this pattern using both a human specimen and rat models. In the human specimen, a substantial fraction of infiltrating tumor cells were located along perivascular spaces in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Falchetti, Maria Laura, D'Alessandris, Quintino Giorgio, Pacioni, Simone, Buccarelli, Mariachiara, Morgante, Liliana, Giannetti, Stefano, Lulli, Valentina, Martini, Maurizio, Larocca, Luigi Maria, Vakana, Eliza, Stancato, Louis, Ricci‐Vitiani, Lucia, Pallini, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2018
Materias:	Molecular Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590500/ https://www.ncbi.nlm.nih.gov/pubmed/30414187 http://dx.doi.org/10.1002/ijc.31983

Ejemplares similares

Brain Invasion along Perivascular Spaces by Glioma Cells: Relationship with Blood–Brain Barrier
por: Pacioni, Simone, et al.
Publicado: (2019)

Human mesenchymal stromal cells inhibit tumor growth in orthotopic glioblastoma xenografts
por: Pacioni, Simone, et al.
Publicado: (2017)

Dilation of Brain Veins and Perivascular Infiltration by Glioblastoma Cells in an In Vivo Assay of Early Tumor Angiogenesis
por: D'Alessandris, Quintino Giorgio, et al.
Publicado: (2021)

Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis
por: Buccarelli, Mariachiara, et al.
Publicado: (2018)

A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology
por: Tate, Courtney M., et al.
Publicado: (2015)

A three‐microRNA signature identifies two subtypes of glioblastoma patients with different clinical outcomes
por: Marziali, Giovanna, et al.
Publicado: (2017)

Characterization of Glioblastoma Cells Response to Regorafenib
por: Mongiardi, Maria Patrizia, et al.
Publicado: (2022)

Development and Validation of a HPLC–MS/MS Method to Measure Nifuroxazide and Its Application in Healthy and Glioblastoma-Bearing Mice
por: Ceruti, Tommaso, et al.
Publicado: (2022)

FMRP modulates the Wnt signalling pathway in glioblastoma
por: Pedini, Giorgia, et al.
Publicado: (2022)

miR-135b suppresses tumorigenesis in glioblastoma stem-like cells impairing proliferation, migration and self-renewal
por: Lulli, Valentina, et al.
Publicado: (2015)

Glioblastoma Stem-Like Cells (GSCs) with Mesenchymal Signature: Lipid Profiles of Mobile Lipids Obtained with MRS before and after Radio/Chemical Treatments
por: Grande, Sveva, et al.
Publicado: (2022)

Short tandem repeat profiling for the authentication of cancer stem‐like cells
por: Visconti, Paola, et al.
Publicado: (2020)

Mesenchymal stromal cells loaded with paclitaxel induce cytotoxic damage in glioblastoma brain xenografts
por: Pacioni, Simone, et al.
Publicado: (2015)

Deregulated expression of the imprinted DLK1-DIO3 region in glioblastoma stemlike cells: tumor suppressor role of lncRNA MEG3
por: Buccarelli, Mariachiara, et al.
Publicado: (2020)

5-Aminolevulinic Acid (5-ALA)-Induced Protoporphyrin IX Fluorescence by Glioma Cells—A Fluorescence Microscopy Clinical Study
por: Pacioni, Simone, et al.
Publicado: (2022)

Effects of the Combined Treatment with a G-Quadruplex-Stabilizing Ligand and Photon Beams on Glioblastoma Stem-like Cells: A Magnetic Resonance Study
por: Palma, Alessandra, et al.
Publicado: (2021)

VEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy in recurrent glioblastoma
por: Martini, Maurizio, et al.
Publicado: (2018)

Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth
por: Buccarelli, Mariachiara, et al.
Publicado: (2021)

Mir-370-3p Impairs Glioblastoma Stem-Like Cell Malignancy Regulating a Complex Interplay between HMGA2/HIF1A and the Oncogenic Long Non-Coding RNA (lncRNA) NEAT1
por: Lulli, Valentina, et al.
Publicado: (2020)

Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome
por: Marziali, G., et al.
Publicado: (2016)

Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth
por: Sighel, Denise, et al.
Publicado: (2021)

Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome
por: Cesarini, Valeriana, et al.
Publicado: (2017)

Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF
por: Cheng, Guo, et al.
Publicado: (2014)

Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo
por: Signore, M, et al.
Publicado: (2014)

Hypoxia, Inflammation and Necrosis as Determinants of Glioblastoma Cancer Stem Cells Progression
por: Papale, Marco, et al.
Publicado: (2020)

Glioblastoma-Specific Strategies of Vascularization: Implications in Anti-Angiogenic Therapy Resistance
por: Buccarelli, Mariachiara, et al.
Publicado: (2022)

Biomarkers for glioblastoma multiforme: status quo
por: Montano, Nicola, et al.
Publicado: (2016)

Effectiveness of Flattening-Filter-Free versus Flattened Beams in V79 and Glioblastoma Patient-Derived Stem-like Cells
por: Dini, Valentina, et al.
Publicado: (2023)

Plxdc2 Is a Mitogen for Neural Progenitors
por: Miller-Delaney, Suzanne F. C., et al.
Publicado: (2011)

Anticancer Properties of the Antipsychotic Drug Chlorpromazine and Its Synergism With Temozolomide in Restraining Human Glioblastoma Proliferation In Vitro
por: Matteoni, Silvia, et al.
Publicado: (2021)

Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis
por: Lauretti, Liverana, et al.
Publicado: (2022)

Paths of Evolution of Progressive Anaplastic Meningiomas: A Clinical and Molecular Pathology Study
por: Di Bonaventura, Rina, et al.
Publicado: (2023)

MiR-378a-3p Acts as a Tumor Suppressor in Colorectal Cancer Stem-Like Cells and Affects the Expression of MALAT1 and NEAT1 lncRNAs
por: Castellani, Giorgia, et al.
Publicado: (2022)

Metabolic Heterogeneity Evidenced by MRS among Patient-Derived Glioblastoma Multiforme Stem-Like Cells Accounts for Cell Clustering and Different Responses to Drugs
por: Grande, Sveva, et al.
Publicado: (2018)

Neuromodulation for Brain Tumors: Myth or Reality? A Narrative Review
por: D’Alessandris, Quintino Giorgio, et al.
Publicado: (2023)

Different Mechanisms Underlie the Metabolic Response of GBM Stem-Like Cells to Ionizing Radiation: Biological and MRS Studies on Effects of Photons and Carbon Ions
por: Palma, Alessandra, et al.
Publicado: (2020)

Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV)
por: Großkopf, Anna K., et al.
Publicado: (2021)

G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells
por: Berardinelli, F., et al.
Publicado: (2019)

A Method to Assess Target Gene Involvement in Angiogenesis In Vitro and In Vivo Using Lentiviral Vectors Expressing shRNA
por: Blosser, Wayne, et al.
Publicado: (2014)

The importance of pre-operative neuroanatomical study in the surgical treatment of trigeminal neuralgia associated with multiple sclerosis
por: Montano, Nicola, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_aq0u5gpddb9t8816q4t9q9po4n