Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

Inhibitors of the 20S proteasome such as bortezomib are cytotoxic to tumor cells and have been proven to be valuable for the clinical management of multiple myeloma. The therapeutic efficacy of bortezomib is, however, hampered by the emergence of acquired resistance. Available data suggest that bloc...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaonan, Espinosa, Belén, Saei, Amir Ata, D'Arcy, Padraig, Zubarev, Roman A., Linder, Stig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590552/
https://www.ncbi.nlm.nih.gov/pubmed/31281566
http://dx.doi.org/10.1155/2019/1659468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590552/
https://www.ncbi.nlm.nih.gov/pubmed/31281566
http://dx.doi.org/10.1155/2019/1659468

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