Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP

P2X3 receptor channels expressed in sensory neurons are activated by extracellular ATP and serve important roles in nociception and sensory hypersensitization, making them attractive therapeutic targets. Although several P2X3 structures are known, it is unclear how physiologically abundant Ca(2+)-AT...

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Detalles Bibliográficos
Autores principales: Li, Mufeng, Wang, Yao, Banerjee, Rahul, Marinelli, Fabrizio, Silberberg, Shai, Faraldo-Gómez, José D, Hattori, Motoyuki, Swartz, Kenton Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590987/
https://www.ncbi.nlm.nih.gov/pubmed/31232692
http://dx.doi.org/10.7554/eLife.47060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590987/
https://www.ncbi.nlm.nih.gov/pubmed/31232692
http://dx.doi.org/10.7554/eLife.47060

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