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Propensity of a picornavirus polymerase to slip on potyvirus-derived transcriptional slippage sites

The substitution rates of viral polymerases have been studied extensively. However less is known about the tendency of these enzymes to ‘slip’ during RNA synthesis to produce progeny RNAs with nucleotide insertions or deletions. We recently described the functional utilization of programmed polymera...

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Detalles Bibliográficos
Autores principales: Stewart, Hazel, Olspert, Allan, Butt, Benjamin G., Firth, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591135/
https://www.ncbi.nlm.nih.gov/pubmed/30507373
http://dx.doi.org/10.1099/jgv.0.001189