HER3 targeting potentiates growth suppressive effects of the PI3K inhibitor BYL719 in pre-clinical models of head and neck squamous cell carcinoma

BYL719 is a PI3K inhibitor that has demonstrated efficacy in the treatment of head and neck squamous cell carcinoma. BYL719 exerts its therapeutic effect by suppressing AKT and other proliferative signaling mechanisms. Despite PI3K inhibition and AKT suppression, residual activity of protein S6, a c...

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Detalles Bibliográficos
Autores principales: Meister, Kara S., Godse, Neal R., Khan, Nayel I., Hedberg, Matthew L., Kemp, Carolyn, Kulkarni, Sucheta, Alvarado, Diego, LaVallee, Theresa, Kim, Seungwon, Grandis, Jennifer R., Duvvuri, Umamaheswar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591241/
https://www.ncbi.nlm.nih.gov/pubmed/31235758
http://dx.doi.org/10.1038/s41598-019-45589-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591241/
https://www.ncbi.nlm.nih.gov/pubmed/31235758
http://dx.doi.org/10.1038/s41598-019-45589-y

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