Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation

A unique bifunctional enzyme, isocitrate dehydrogenase kinase/phosphatase (AceK) regulates isocitrate dehydrogenase (IDH) by phosphorylation and dephosphorylation in response to nutrient availability. Herein we report the crystal structure of AceK in complex with ADP and Mn(2+) ions. Although the ov...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoying, Shen, Qingya, Lei, Zhen, Wang, Qianyi, Zheng, Jimin, Jia, Zongchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591243/
https://www.ncbi.nlm.nih.gov/pubmed/31235769
http://dx.doi.org/10.1038/s41598-019-45704-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591243/
https://www.ncbi.nlm.nih.gov/pubmed/31235769
http://dx.doi.org/10.1038/s41598-019-45704-z

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