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Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation
A unique bifunctional enzyme, isocitrate dehydrogenase kinase/phosphatase (AceK) regulates isocitrate dehydrogenase (IDH) by phosphorylation and dephosphorylation in response to nutrient availability. Herein we report the crystal structure of AceK in complex with ADP and Mn(2+) ions. Although the ov...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591243/ https://www.ncbi.nlm.nih.gov/pubmed/31235769 http://dx.doi.org/10.1038/s41598-019-45704-z |