The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif

Epidermal growth factor receptor (EGFR) and its downstream phosphoinositide 3-kinase (PI3K) pathway are commonly deregulated in cancer. Recently, we have shown that the IQ motif-containing GTPase-activating protein 1 (IQGAP1) provides a molecular platform to scaffold all the components of the PI3K-A...

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Detalles Bibliográficos
Autores principales: Chen, Mo, Choi, Suyong, Jung, Oisun, Wen, Tianmu, Baum, Christina, Thapa, Narendra, Lambert, Paul F., Rapraeger, Alan C., Anderson, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591252/
https://www.ncbi.nlm.nih.gov/pubmed/31235839
http://dx.doi.org/10.1038/s41598-019-45671-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591252/
https://www.ncbi.nlm.nih.gov/pubmed/31235839
http://dx.doi.org/10.1038/s41598-019-45671-5

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