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Modeling the Hematopoietic Landscape
Some time ago, we proposed a continuum-like view of the lineages open to hematopoietic stem cells (HSCs); each HSC self-renews or chooses from the spectrum of all end-cell options and can then “merely” differentiate. Having selected a cell lineage, an individual HSC may still “step sideways” to an a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591273/ https://www.ncbi.nlm.nih.gov/pubmed/31275935 http://dx.doi.org/10.3389/fcell.2019.00104 |
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author | Brown, Geoffrey Ceredig, Rhodri |
author_facet | Brown, Geoffrey Ceredig, Rhodri |
author_sort | Brown, Geoffrey |
collection | PubMed |
description | Some time ago, we proposed a continuum-like view of the lineages open to hematopoietic stem cells (HSCs); each HSC self-renews or chooses from the spectrum of all end-cell options and can then “merely” differentiate. Having selected a cell lineage, an individual HSC may still “step sideways” to an alternative, albeit closely related, fate: HSC and their progeny therefore remain versatile. The hematopoietic cytokines erythropoietin, granulocyte colony-stimulating factor, macrophage colony-stimulating factor, granulocyte/macrophage colony-stimulating factor and ligand for the fms-like tyrosine kinase 3 instruct cell lineage. Sub-populations of HSCs express each of the cytokine receptors that are positively auto-regulated upon cytokine binding. Many years ago, Waddington proposed that the epigenetic landscape played an important role in cell lineage choice. This landscape is dynamic and unstable especially regarding DNA methylation patterns across genomic DNA. This may underlie the receptor diversity of HSC and their decision-making. |
format | Online Article Text |
id | pubmed-6591273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65912732019-07-02 Modeling the Hematopoietic Landscape Brown, Geoffrey Ceredig, Rhodri Front Cell Dev Biol Cell and Developmental Biology Some time ago, we proposed a continuum-like view of the lineages open to hematopoietic stem cells (HSCs); each HSC self-renews or chooses from the spectrum of all end-cell options and can then “merely” differentiate. Having selected a cell lineage, an individual HSC may still “step sideways” to an alternative, albeit closely related, fate: HSC and their progeny therefore remain versatile. The hematopoietic cytokines erythropoietin, granulocyte colony-stimulating factor, macrophage colony-stimulating factor, granulocyte/macrophage colony-stimulating factor and ligand for the fms-like tyrosine kinase 3 instruct cell lineage. Sub-populations of HSCs express each of the cytokine receptors that are positively auto-regulated upon cytokine binding. Many years ago, Waddington proposed that the epigenetic landscape played an important role in cell lineage choice. This landscape is dynamic and unstable especially regarding DNA methylation patterns across genomic DNA. This may underlie the receptor diversity of HSC and their decision-making. Frontiers Media S.A. 2019-06-18 /pmc/articles/PMC6591273/ /pubmed/31275935 http://dx.doi.org/10.3389/fcell.2019.00104 Text en Copyright © 2019 Brown and Ceredig. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Brown, Geoffrey Ceredig, Rhodri Modeling the Hematopoietic Landscape |
title | Modeling the Hematopoietic Landscape |
title_full | Modeling the Hematopoietic Landscape |
title_fullStr | Modeling the Hematopoietic Landscape |
title_full_unstemmed | Modeling the Hematopoietic Landscape |
title_short | Modeling the Hematopoietic Landscape |
title_sort | modeling the hematopoietic landscape |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591273/ https://www.ncbi.nlm.nih.gov/pubmed/31275935 http://dx.doi.org/10.3389/fcell.2019.00104 |
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