Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics

Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites. Here, we performed omics-driven knowledge-bas...

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Detalles Bibliográficos
Autores principales: Tyagi, Rahul, Elfawal, Mostafa A., Wildman, Scott A., Helander, Jon, Bulman, Christina A., Sakanari, Judy, Rosa, Bruce A., Brindley, Paul J., Janetka, James W., Aroian, Raffi V., Mitreva, Makedonka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591293/
https://www.ncbi.nlm.nih.gov/pubmed/31235822
http://dx.doi.org/10.1038/s41598-019-45548-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591293/
https://www.ncbi.nlm.nih.gov/pubmed/31235822
http://dx.doi.org/10.1038/s41598-019-45548-7

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