Dual β-lactam combination therapy for multi-drug resistant Pseudomonas aeruginosa infection: enhanced efficacy in vivo and comparison with monotherapies of penicillin-binding protein inhibition

The aim of the study was to determine the efficacy of dual β-lactam combination treatments derived from eight approved drugs against Galleria mellonella larvae infected with MDR strains of P. aeruginosa. Carbapenem-resistant P. aeruginosa NCTC 13437 and an unrelated clinical isolate were used to inf...

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Detalles Bibliográficos
Autores principales: Siriyong, Thanyaluck, Murray, Rachael M., Bidgood, Lucy E., Young, Simon A., Wright, Florence, Parcell, Benjamin J., Voravuthikunchai, Supayang Piyawan, Coote, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591303/
https://www.ncbi.nlm.nih.gov/pubmed/31235728
http://dx.doi.org/10.1038/s41598-019-45550-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591303/
https://www.ncbi.nlm.nih.gov/pubmed/31235728
http://dx.doi.org/10.1038/s41598-019-45550-z

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