Neutrophil GM-CSF signaling in inflammatory bowel disease patients is influenced by non-coding genetic variants

Neutrophil dysfunction and GM-CSF auto-antibodies are observed in pediatric and adult patients with Crohn’s disease (CD). We associated damaging coding variants with low GM-CSF induced STAT5 stimulation index (GMSI) in pediatric CD patients and implicated variation of neutrophil GM-CSF signaling in...

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Detalles Bibliográficos
Autores principales: Venkateswaran, Suresh, Denson, Lee A., Jurickova, Ingrid, Dodd, Anne, Zwick, Michael E., Cutler, David J., Kugathasan, Subra, Okou, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591305/
https://www.ncbi.nlm.nih.gov/pubmed/31235766
http://dx.doi.org/10.1038/s41598-019-45701-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591305/
https://www.ncbi.nlm.nih.gov/pubmed/31235766
http://dx.doi.org/10.1038/s41598-019-45701-2

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