Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer

G protein-coupled receptors (GPCRs) can integrate extracellular signals via allosteric interactions within dimers and higher-order oligomers. However, the structural bases of these interactions remain unclear. Here, we use the GABA(B) receptor heterodimer as a model as it forms large complexes in th...

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Detalles Bibliográficos
Autores principales: Xue, Li, Sun, Qian, Zhao, Han, Rovira, Xavier, Gai, Siyu, He, Qianwen, Pin, Jean-Philippe, Liu, Jianfeng, Rondard, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591306/
https://www.ncbi.nlm.nih.gov/pubmed/31235691
http://dx.doi.org/10.1038/s41467-019-10834-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591306/
https://www.ncbi.nlm.nih.gov/pubmed/31235691
http://dx.doi.org/10.1038/s41467-019-10834-5

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