Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

The coactivator PGC-1α1 is activated by exercise training in skeletal muscle and promotes fatigue-resistance. In exercised muscle, PGC-1α1 enhances the expression of kynurenine aminotransferases (Kats), which convert kynurenine into kynurenic acid. This reduces kynurenine-associated neurotoxicity an...

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Detalles Bibliográficos
Autores principales: Agudelo, Leandro Z., Ferreira, Duarte M. S., Dadvar, Shamim, Cervenka, Igor, Ketscher, Lars, Izadi, Manizheh, Zhengye, Liu, Furrer, Regula, Handschin, Christoph, Venckunas, Tomas, Brazaitis, Marius, Kamandulis, Sigitas, Lanner, Johanna T., Ruas, Jorge L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591322/
https://www.ncbi.nlm.nih.gov/pubmed/31235694
http://dx.doi.org/10.1038/s41467-019-10712-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591322/
https://www.ncbi.nlm.nih.gov/pubmed/31235694
http://dx.doi.org/10.1038/s41467-019-10712-0

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