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Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression
Parkinson’s disease (PD) represents an increasing problem in society. The oligomerization of alpha-synuclein (αSyn) is a suggested key event in its pathogenesis, yet the pathological modes of action remain to be fully elucidated. To identify potential disease-modifying therapeutics and to study αSyn...
Autores principales: | Bartels, Martin, Weckbecker, Daniel, Kuhn, Peer-Hendrik, Ryazanov, Sergey, Leonov, Andrei, Griesinger, Christian, Lichtenthaler, Stefan F., Bötzel, Kai, Giese, Armin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591385/ https://www.ncbi.nlm.nih.gov/pubmed/31235814 http://dx.doi.org/10.1038/s41598-019-45298-6 |
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