Dual Ca(2+)-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations

Mutations of human BEST1, encoding a Ca(2+)-activated Cl(−) channel (hBest1), cause macular degenerative disorders. Best1 homolog structures reveal an evolutionarily conserved channel architecture highlighted by two landmark restrictions (named the “neck” and “aperture”, respectively) in the ion con...

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Detalles Bibliográficos
Autores principales: Ji, Changyi, Kittredge, Alec, Hopiavuori, Austin, Ward, Nancy, Chen, Shoudeng, Fukuda, Yohta, Zhang, Yu, Yang, Tingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591409/
https://www.ncbi.nlm.nih.gov/pubmed/31263784
http://dx.doi.org/10.1038/s42003-019-0433-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591409/
https://www.ncbi.nlm.nih.gov/pubmed/31263784
http://dx.doi.org/10.1038/s42003-019-0433-3

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