Efficacy of Human Exposures of Gepotidacin (GSK2140944) against Escherichia coli in a Rat Pyelonephritis Model

Gepotidacin is a first-in-class triazaacenaphthylene antibacterial that inhibits bacterial type II topoisomerases and has in vitro activity against a range of bacterial pathogens, including Escherichia coli. Urinary tract infections often progress to pyelonephritis and are a worldwide problem due to...

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Detalles Bibliográficos
Autores principales: Hoover, Jennifer L., Singley, Christine M., Elefante, Philippa, Rittenhouse, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591613/
https://www.ncbi.nlm.nih.gov/pubmed/31061153
http://dx.doi.org/10.1128/AAC.00086-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591613/
https://www.ncbi.nlm.nih.gov/pubmed/31061153
http://dx.doi.org/10.1128/AAC.00086-19

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