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Efficacy of Human Exposures of Gepotidacin (GSK2140944) against Escherichia coli in a Rat Pyelonephritis Model

Gepotidacin is a first-in-class triazaacenaphthylene antibacterial that inhibits bacterial type II topoisomerases and has in vitro activity against a range of bacterial pathogens, including Escherichia coli. Urinary tract infections often progress to pyelonephritis and are a worldwide problem due to...

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Detalles Bibliográficos
Autores principales:	Hoover, Jennifer L., Singley, Christine M., Elefante, Philippa, Rittenhouse, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591613/ https://www.ncbi.nlm.nih.gov/pubmed/31061153 http://dx.doi.org/10.1128/AAC.00086-19

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