Cargando…

Human Genomic Safe Harbors and the Suicide Gene‐Based Safeguard System for iPSC‐Based Cell Therapy

The use of human induced pluripotent stem cells (hiPSCs) and recent advances in cell engineering have opened new prospects for cell‐based therapy. However, there are concerns that must be addressed prior to their broad clinical applications and a major concern is tumorigenicity. Suicide gene approac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kimura, Yasuyoshi, Shofuda, Tomoko, Higuchi, Yuichiro, Nagamori, Ippei, Oda, Masaaki, Nakamori, Masayuki, Onodera, Masafumi, Kanematsu, Daisuke, Yamamoto, Atsuyo, Katsuma, Asako, Suemizu, Hiroshi, Nakano, Toru, Kanemura, Yonehiro, Mochizuki, Hideki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2019
Materias:	Pluripotent Stem Cells
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591650/ https://www.ncbi.nlm.nih.gov/pubmed/30887735 http://dx.doi.org/10.1002/sctm.18-0039

Ejemplares similares

Patient-Specific iPSC-Derived Models Link Aberrant Endoplasmic Reticulum Stress Sensing and Response to Juvenile Osteochondritis Dissecans Etiology
por: Salazar-Noratto, Giuliana E, et al.
Publicado: (2023)

Correlation Between Genetic Abnormalities in Induced Pluripotent Stem Cell-Derivatives and Abnormal Tissue Formation in Tumorigenicity Tests
por: Yamamoto, Takako, et al.
Publicado: (2022)

Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line‐ and method‐dependent
por: Chichagova, Valeria, et al.
Publicado: (2019)

Feeder-Free Generation and Long-Term Culture of Human Induced Pluripotent Stem Cells Using Pericellular Matrix of Decidua Derived Mesenchymal Cells
por: Fukusumi, Hayato, et al.
Publicado: (2013)

Self-Assembled Matrigel-Free iPSC-Derived Liver Organoids Demonstrate Wide-Ranging Highly Differentiated Liver Functions
por: Weng, Yun, et al.
Publicado: (2022)

Biallelic correction of sickle cell disease‐derived induced pluripotent stem cells (iPSCs) confirmed at the protein level through serum‐free iPS‐sac/erythroid differentiation
por: Haro‐Mora, Juan J., et al.
Publicado: (2020)

Optogenetic Reporters Delivered as mRNA Facilitate Repeatable Action Potential and Calcium Handling Assessment in Human iPSC-Derived Cardiomyocytes
por: Yiangou, Loukia, et al.
Publicado: (2022)

Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases
por: Sugai, Keiko, et al.
Publicado: (2016)

TB-8 Genetic and molecular properties of long-term proliferating tumorsphere -forming glioma derived cells
por: Kijima, Noriyuki, et al.
Publicado: (2021)

Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease
por: Giacalone, Joseph C., et al.
Publicado: (2016)

Robust Differentiation of mRNA-Reprogrammed Human Induced Pluripotent Stem Cells Toward a Retinal Lineage
por: Sridhar, Akshayalakshmi, et al.
Publicado: (2016)

Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells
por: Jackson, Melany, et al.
Publicado: (2016)

Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells
por: Grow, Douglas A., et al.
Publicado: (2016)

Human Induced Pluripotent Stem Cells Differentiate Into Functional Mesenchymal Stem Cells and Repair Bone Defects
por: Sheyn, Dmitriy, et al.
Publicado: (2016)

A Novel Protocol for Directed Differentiation of C9orf72-Associated Human Induced Pluripotent Stem Cells Into Contractile Skeletal Myotubes
por: Swartz, Elliot W., et al.
Publicado: (2016)

Concise Review: Towards the Clinical Translation of Induced Pluripotent Stem Cell‐Derived Blood Cells—Ready for Take‐Off
por: Haake, Kathrin, et al.
Publicado: (2018)

Concise Review: Precision Matchmaking: Induced Pluripotent Stem Cells Meet Cardio‐Oncology
por: Nair, Pooja, et al.
Publicado: (2019)

Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells via Hepatocyte Growth Factor/c‐Met Signaling in Obesity‐Associated Kidney Injury
por: Li, Bin, et al.
Publicado: (2019)

Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell‐Derived Hepatocytes for Cell‐Based Therapy
por: Blackford, Samuel J.I., et al.
Publicado: (2018)

Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons
por: Xue, Yingchao, et al.
Publicado: (2018)

Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions
por: Gandhi, Jarel K., et al.
Publicado: (2019)

Precision installation of a highly efficient suicide gene safety switch in human induced pluripotent stem cells
por: Shi, Zhong‐Dong, et al.
Publicado: (2020)

Grafted human pluripotent stem cell‐derived cortical neurons integrate into adult human cortical neural circuitry
por: Grønning Hansen, Marita, et al.
Publicado: (2020)

Stimulation of L‐type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells
por: Jefri, Malvin, et al.
Publicado: (2020)

Endothelial cells derived from patients' induced pluripotent stem cells for sustained factor VIII delivery and the treatment of hemophilia A
por: Rose, Melanie, et al.
Publicado: (2020)

Complement modulation reverses pathology in Y402H‐retinal pigment epithelium cell model of age‐related macular degeneration by restoring lysosomal function
por: Cerniauskas, Edvinas, et al.
Publicado: (2020)

Cystic renal‐epithelial derived induced pluripotent stem cells from polycystic kidney disease patients
por: Kenter, Annegien T., et al.
Publicado: (2020)

Stem cell‐derived retinal pigment epithelium from patients with age‐related macular degeneration exhibit reduced metabolism and matrix interactions
por: Gong, Jie, et al.
Publicado: (2019)

Pluripotent stem cell‐based screening identifies CUDC‐907 as an effective compound for restoring the in vitro phenotype of Nakajo‐Nishimura syndrome
por: Kase, Naoya, et al.
Publicado: (2020)

Chromatin accessibility in canine stromal cells and its implications for canine somatic cell reprogramming
por: Questa, Maria, et al.
Publicado: (2020)

Window of opportunity for human amnion epithelial stem cells to attenuate astrogliosis after umbilical cord occlusion in preterm fetal sheep
por: Davidson, Joanne O., et al.
Publicado: (2020)

CD73 expression is critical to therapeutic effects of human endometrial regenerative cells in inhibition of cardiac allograft rejection in mice
por: Hu, Yonghao, et al.
Publicado: (2020)

Synthetic mRNA‐based differentiation method enables early detection of Parkinson's phenotypes in neurons derived from Gaucher disease‐induced pluripotent stem cells
por: Akiyama, Tomohiko, et al.
Publicado: (2020)

High‐throughput screening in postimplantation haploid epiblast stem cells reveals Hs3st3b1 as a modulator for reprogramming
por: Gao, Qian, et al.
Publicado: (2021)

Neurotrophin‐3 contributes to benefits of human embryonic stem cell‐derived cardiovascular progenitor cells against reperfused myocardial infarction
por: Bi, Wei, et al.
Publicado: (2021)

Enhanced differentiation of human induced pluripotent stem cells toward the midbrain dopaminergic neuron lineage through GLYPICAN‐4 downregulation
por: Corti, Serena, et al.
Publicado: (2021)

Culture substrate‐associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells
por: Yamashita, Akihiro, et al.
Publicado: (2020)

Video bioinformatics analysis of human pluripotent stem cell morphology, quality, and cellular dynamics
por: Lin, Sabrina C., et al.
Publicado: (2021)

pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation
por: Rozanska, Agata, et al.
Publicado: (2022)

Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1
por: Srikanth, Manasa P., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nq5c6i7mjhf76mni8oh5gpvo5d