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Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations

BACKGROUND: Succinate dehydrogenase (SDH) loss and mastermind-like 3 (MAML3) translocation are two clinically important genetic alterations that correlate with increased rates of metastasis in subtypes of human paraganglioma and pheochromocytoma (PPGL) neuroendocrine tumors. Although hypotheses prop...

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Detalles Bibliográficos
Autores principales: Smestad, John A., Maher, L. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591808/
https://www.ncbi.nlm.nih.gov/pubmed/31234811
http://dx.doi.org/10.1186/s12885-019-5813-z