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Inhibition of neddylation induces mitotic defects and alters MKLP1 accumulation at the midbody during cytokinesis
The cullin-RING E3 ubiquitin ligases (CRLs) play crucial roles in modulating the stability of proteins in the cell and are, in turn, regulated by post-translational modification by the ubiquitin-like (Ubl) protein NEDD8. This process, termed neddylation, is reversible through the action of the COP9...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592236/ https://www.ncbi.nlm.nih.gov/pubmed/31057046 http://dx.doi.org/10.1080/15384101.2019.1612696 |