tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay

Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during the unfolded protein response (UPR). The UPR regulates the protein folding capacity of the endoplasmic reticulum (ER). ER stres...

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Detalles Bibliográficos
Autores principales: Peschek, Jirka, Walter, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592678/
https://www.ncbi.nlm.nih.gov/pubmed/31237564
http://dx.doi.org/10.7554/eLife.44199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592678/
https://www.ncbi.nlm.nih.gov/pubmed/31237564
http://dx.doi.org/10.7554/eLife.44199

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