CG-dinucleotide suppression enables antiviral defense targeting non-self RNA

Vertebrate genomes exhibit marked CG-suppression, that is lower than expected numbers of 5′-CG-3′ dinucleotides(1). This feature is likely due to C-to-T mutations that have accumulated over hundreds of millions of years, driven by CG-specific DNA methyl transferases and spontaneous methyl-cytosine d...

Descripción completa

Detalles Bibliográficos
Autores principales: Takata, Matthew A., Gonçalves-Carneiro, Daniel, Zang, Trinity, Soll, Steven J., York, Ashley, Blanco-Melo, Daniel, Bieniasz, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592701/
https://www.ncbi.nlm.nih.gov/pubmed/28953888
http://dx.doi.org/10.1038/nature24039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592701/
https://www.ncbi.nlm.nih.gov/pubmed/28953888
http://dx.doi.org/10.1038/nature24039

Ejemplares similares