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Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation
Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer pathogenicity; however, the direct targets and mechanisms by which nimbolide exerts its effects are poorly understood. Here, we used activity-based protein profiling (ABPP) chemoproteomic platforms to discover that nim...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592714/ https://www.ncbi.nlm.nih.gov/pubmed/31209351 http://dx.doi.org/10.1038/s41589-019-0304-8 |