Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation

Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer pathogenicity; however, the direct targets and mechanisms by which nimbolide exerts its effects are poorly understood. Here, we used activity-based protein profiling (ABPP) chemoproteomic platforms to discover that nim...

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Detalles Bibliográficos
Autores principales: Spradlin, Jessica N., Hu, Xirui, Ward, Carl C., Brittain, Scott M., Jones, Michael D., Ou, Lisha, To, Milton, Proudfoot, Andrew, Ornelas, Elizabeth, Woldegiorgis, Mikias, Olzmann, James A., Bussiere, Dirksen E., Thomas, Jason R., Tallarico, John A., McKenna, Jeffrey M., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592714/
https://www.ncbi.nlm.nih.gov/pubmed/31209351
http://dx.doi.org/10.1038/s41589-019-0304-8

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