Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

Ligand-dependent protein degradation has emerged as a compelling strategy to pharmacologically control the protein content of cells. So far, however, only a limited number of E3 ligases have been found to support this process. Here, we use a chemical proteomic strategy that leverages broadly reactiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xiaoyu, Crowley, Vincent M., Wucherpfennig, Thomas G., Dix, Melissa M., Cravatt, Benjamin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592777/
https://www.ncbi.nlm.nih.gov/pubmed/31209349
http://dx.doi.org/10.1038/s41589-019-0279-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592777/
https://www.ncbi.nlm.nih.gov/pubmed/31209349
http://dx.doi.org/10.1038/s41589-019-0279-5

Ejemplares similares