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Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
Ligand-dependent protein degradation has emerged as a compelling strategy to pharmacologically control the protein content of cells. So far, however, only a limited number of E3 ligases have been found to support this process. Here, we use a chemical proteomic strategy that leverages broadly reactiv...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592777/ https://www.ncbi.nlm.nih.gov/pubmed/31209349 http://dx.doi.org/10.1038/s41589-019-0279-5 |