In vivo profiling of metastatic double knockouts through CRISPR-Cpf1 screens

The genetic interactions influencing metastatic potential have been challenging to investigate systematically. Here we developed MCAP (massively parallel CRISPR-Cpf1/Cas12a crRNA array profiling), an approach for combinatorial interrogation of double knockouts in vivo. We designed an MCAP library of...

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Detalles Bibliográficos
Autores principales: Chow, Ryan D., Wang, Guangchuan, Ye, Lupeng, Codina, Adan, Kim, Hyunu Ray, Shen, Li, Dong, Matthew B., Errami, Youssef, Chen, Sidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592845/
https://www.ncbi.nlm.nih.gov/pubmed/30962622
http://dx.doi.org/10.1038/s41592-019-0371-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592845/
https://www.ncbi.nlm.nih.gov/pubmed/30962622
http://dx.doi.org/10.1038/s41592-019-0371-5

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