Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody

The microtubule-associated protein tau is an attractive therapeutic target for the treatment of Alzheimer’s disease and related tauopathies as its aggregation strongly correlates with disease progression and is considered a key mediator of neuronal toxicity. Delivery of most therapeutics to the brai...

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Detalles Bibliográficos
Autores principales: Janowicz, Phillip W., Leinenga, Gerhard, Götz, Jürgen, Nisbet, Rebecca M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592925/
https://www.ncbi.nlm.nih.gov/pubmed/31239479
http://dx.doi.org/10.1038/s41598-019-45577-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592925/
https://www.ncbi.nlm.nih.gov/pubmed/31239479
http://dx.doi.org/10.1038/s41598-019-45577-2

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