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Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody

The microtubule-associated protein tau is an attractive therapeutic target for the treatment of Alzheimer’s disease and related tauopathies as its aggregation strongly correlates with disease progression and is considered a key mediator of neuronal toxicity. Delivery of most therapeutics to the brai...

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Detalles Bibliográficos
Autores principales:	Janowicz, Phillip W., Leinenga, Gerhard, Götz, Jürgen, Nisbet, Rebecca M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592925/ https://www.ncbi.nlm.nih.gov/pubmed/31239479 http://dx.doi.org/10.1038/s41598-019-45577-2

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