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Mechanisms of Ca(2+)/calmodulin-dependent kinase II activation in single dendritic spines

CaMKIIα plays an essential role in decoding Ca(2+) signaling in spines by acting as a leaky Ca(2+) integrator with the time constant of several seconds. However, the mechanism by which CaMKIIα integrates Ca(2+) signals remains elusive. Here, we imaged CaMKIIα-CaM association in single dendritic spin...

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Detalles Bibliográficos
Autores principales: Chang, Jui-Yun, Nakahata, Yoshihisa, Hayano, Yuki, Yasuda, Ryohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592955/
https://www.ncbi.nlm.nih.gov/pubmed/31239443
http://dx.doi.org/10.1038/s41467-019-10694-z