Characterization of Porcine Hepatic and Intestinal Drug Metabolizing CYP450: Comparison with Human Orthologues from A Quantitative, Activity and Selectivity Perspective

Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism. Porcine CYP450 has been demonstrated to convert typical substrates of human CYP450. Ne...

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Detalles Bibliográficos
Autores principales: Schelstraete, Wim, Clerck, Laura De, Govaert, Elisabeth, Millecam, Joske, Devreese, Mathias, Deforce, Dieter, Bocxlaer, Jan Van, Croubels, Siska
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592956/
https://www.ncbi.nlm.nih.gov/pubmed/31239454
http://dx.doi.org/10.1038/s41598-019-45212-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592956/
https://www.ncbi.nlm.nih.gov/pubmed/31239454
http://dx.doi.org/10.1038/s41598-019-45212-0

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