Cargando…

Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling

Iron deposition in the brain is an early issue in Alzheimer's disease (AD). However, the pathogenesis of iron-induced pathological changes in AD remains elusive. Insulin resistance in brains is an essential feature of AD. Previous studies determined that insulin resistance is involved in the de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wan, Wenbin, Cao, Lan, Kalionis, Bill, Murthi, Padma, Xia, Shijin, Guan, Yangtai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593079/ https://www.ncbi.nlm.nih.gov/pubmed/31275224 http://dx.doi.org/10.3389/fneur.2019.00607

Ejemplares similares

Similarities and Differences in the Pattern of Tau Hyperphosphorylation in Physiological and Pathological Conditions: Impacts on the Elaboration of Therapies to Prevent Tau Pathology
por: Duquette, Antoine, et al.
Publicado: (2021)

Analysis of homeobox gene action may reveal novel angiogenic pathways in normal placental vasculature and in clinical pregnancy disorders associated with abnormal placental angiogenesis.
por: Murthi, Padma, et al.
Publicado: (2014)

Applications of Induced Pluripotent Stem Cells in Studying the Neurodegenerative Diseases
por: Wan, Wenbin, et al.
Publicado: (2015)

The Role of Placental Homeobox Genes in Human Fetal Growth Restriction
por: Murthi, Padma, et al.
Publicado: (2011)

Hyperphosphorylation-Induced Tau Oligomers
por: Iqbal, Khalid, et al.
Publicado: (2013)

The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation
por: Wan, Wenbin, et al.
Publicado: (2016)

The Role of Wnt Signaling in the Development of Alzheimer's Disease: A Potential Therapeutic Target?
por: Wan, Wenbin, et al.
Publicado: (2014)

The Role of Oxidative Stress and Inflammation in Cardiovascular Aging
por: Wu, Junzhen, et al.
Publicado: (2014)

Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction
por: Zhang, Xingyu, et al.
Publicado: (2021)

Lithium Treatment of APPSwDI/NOS2−/− Mice Leads to Reduced Hyperphosphorylated Tau, Increased Amyloid Deposition and Altered Inflammatory Phenotype
por: Sudduth, Tiffany L., et al.
Publicado: (2012)

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration
por: Merkwirth, Carsten, et al.
Publicado: (2012)

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau
por: Melov, Simon, et al.
Publicado: (2007)

Hyperphosphorylated tau in young and middle-aged subjects
por: Elobeid, Adila, et al.
Publicado: (2011)

PINCH in the Cellular Stress Response to Tau-Hyperphosphorylation
por: Ozdemir, Ahmet Yunus, et al.
Publicado: (2013)

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
por: Tepper, Katharina, et al.
Publicado: (2014)

Immunological memory to hyperphosphorylated tau in asymptomatic individuals
por: Pascual, Gabriel, et al.
Publicado: (2017)

Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer’s Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated
por: Barthélemy, Nicolas R., et al.
Publicado: (2022)

Neuronal Deposition of Amyloid-β Oligomers and Hyperphosphorylated Tau Is Closely Connected with Cognitive Dysfunction in Aged Dogs
por: Habiba, Umma, et al.
Publicado: (2021)

Berberine Reduces Aβ(42) Deposition and Tau Hyperphosphorylation via Ameliorating Endoplasmic Reticulum Stress
por: Wu, Yue, et al.
Publicado: (2021)

Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation
por: Huang, Yunpeng, et al.
Publicado: (2014)

Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging
por: Yuan, Minghao, et al.
Publicado: (2022)

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice
por: Chen, Yanxing, et al.
Publicado: (2014)

Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Drosophila Model of Tauopathy and Neuroblastoma Cells
por: Chatterjee, Shreyasi, et al.
Publicado: (2019)

Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice
por: Peng, Liangyu, et al.
Publicado: (2021)

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion
por: Plouffe, Vanessa, et al.
Publicado: (2012)

Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset
por: Rodriguez-Callejas, Juan D., et al.
Publicado: (2016)

The Role of Traditional Chinese Medicine Natural Products in β-Amyloid Deposition and Tau Protein Hyperphosphorylation in Alzheimer’s Disease
por: Yan, Huiying, et al.
Publicado: (2023)

The Reduction of Tau Hyperphosphorylation by Cornel Iridoid Glycosides Is Mediated by Their Influence on Calpain Activity
por: Guo, Kaiwen, et al.
Publicado: (2022)

Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases
por: Duka, Valeriy, et al.
Publicado: (2013)

Time-Specific Pattern of Iron Deposition in Different Regions in Parkinson's Disease Measured by Quantitative Susceptibility Mapping
por: Fu, Xiaodi, et al.
Publicado: (2021)

GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions
por: Zhu, Huazhang, et al.
Publicado: (2018)

Novel insights into D-Pinitol based therapies: a link between tau hyperphosphorylation and insulin resistance
por: Medina-Vera, Dina, et al.
Publicado: (2023)

The Role of α-synuclein and Tau Hyperphosphorylation-Mediated Autophagy and Apoptosis in Lead-induced Learning and Memory Injury
por: Zhang, Jianbin, et al.
Publicado: (2012)

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology
por: Gratuze, Maud, et al.
Publicado: (2017)

Dimethyl Sulfoxide Induces Both Direct and Indirect Tau Hyperphosphorylation
por: Julien, Carl, et al.
Publicado: (2012)

Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice
por: Jung, Ga-young, et al.
Publicado: (2013)

Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
por: Liu, Jin, et al.
Publicado: (2016)

Corrigendum: Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset
por: Rodriguez-Callejas, Juan D., et al.
Publicado: (2017)

Cellular polyamines condense hyperphosphorylated Tau, triggering Alzheimer’s disease
por: Ivanov, Stefan M., et al.
Publicado: (2020)

The Emerging Role of the Prokineticins and Homeobox Genes in the Vascularization of the Placenta: Physiological and Pathological Aspects
por: Alfaidy, Nadia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_m7n6t3ok34lftr8fl3cpc3j4cf