Cargando…

The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice

Breast cancer with bone metastasis is essentially incurable with current anticancer therapies. The bone morphogenetic protein (BMP) pathway is an attractive therapeutic candidate, as it is involved in the bone turnover and in cancer cell formation and their colonization of distant organs such as the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vollaire, Julien, Machuca-Gayet, Irma, Lavaud, Jonathan, Bellanger, Aurélie, Bouazza, Lamia, El Moghrabi, Soumaya, Treilleux, Isabelle, Coll, Jean-Luc, Peyruchaud, Olivier, Josserand, Véronique, Cohen, Pascale A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593094/ https://www.ncbi.nlm.nih.gov/pubmed/31275146 http://dx.doi.org/10.3389/fphar.2019.00667

Ejemplares similares

Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation
por: Horbelt, Daniel, et al.
Publicado: (2015)

Noninvasive monitoring of liver metastasis development via combined multispectral photoacoustic imaging and fluorescence diffuse optical tomography
por: Lavaud, Jonathan, et al.
Publicado: (2020)

Inhibition of BMP signaling with LDN 193189 can influence bone marrow stromal cell fate but does not prevent hypertrophy during chondrogenesis
por: Franco, Rose Ann G., et al.
Publicado: (2022)

Osteoimmunology of Bone Loss in Inflammatory Rheumatic Diseases
por: Coury, Fabienne, et al.
Publicado: (2019)

Autotaxin/Lysophosphatidic Acid Axis: From Bone Biology to Bone Disorders
por: Alioli, Candide, et al.
Publicado: (2022)

Autotaxin-β interaction with the cell surface via syndecan-4 impacts on cancer cell proliferation and metastasis
por: Leblanc, Raphael, et al.
Publicado: (2018)

Tumor-Specific Imaging with Angiostamp800 or Bevacizumab-IRDye 800CW Improves Fluorescence-Guided Surgery over Indocyanine Green in Peritoneal Carcinomatosis
por: Josserand, Véronique, et al.
Publicado: (2022)

Low-Dose Naltrexone (LDN)—Review of Therapeutic Utilization
por: Toljan, Karlo, et al.
Publicado: (2018)

FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells
por: Jia, Tao, et al.
Publicado: (2021)

Jessica Soldavini, MPH, RD, LDN, Wins Huddleson Award
Publicado: (2020)

Blockade of Platelet CysLT1R Receptor with Zafirlukast Counteracts Platelet Protumoral Action and Prevents Breast Cancer Metastasis to Bone and Lung
por: Saier, Lou, et al.
Publicado: (2022)

Response to Cysteamine in Osteoclasts Obtained from Patients with Nephropathic Cystinosis: A Genotype/Phenotype Correlation
por: Quinaux, Thomas, et al.
Publicado: (2021)

Treatment-resistant immune thrombocytopenic purpura associated with LDN use in a patient with MS
por: Torkildsen, Øivind, et al.
Publicado: (2014)

Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN)
por: Chopra, Pradeep, et al.
Publicado: (2013)

Rheumatoid Arthritis in the View of Osteoimmunology
por: Auréal, Mélanie, et al.
Publicado: (2020)

Stapled peptide targeting the CDK4/Cyclin D interface combined with Abemaciclib inhibits KRAS mutant lung cancer growth
por: Bouclier, Celine, et al.
Publicado: (2020)

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain
por: Younger, Jarred, et al.
Publicado: (2014)

Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2
por: Williams, Eleanor, et al.
Publicado: (2018)

Inhibition of UCHL1 by LDN-57444 attenuates Ang II–Induced atrial fibrillation in mice
por: Bi, Hai-Lian, et al.
Publicado: (2019)

LDN Protects Bone Property Deterioration at Different Hierarchical Levels in T2DM Mice Bone
por: Shitole, Pankaj, et al.
Publicado: (2021)

Low-Dose Naltrexone (LDN) for Chronic Pain at a Single Institution: A Case Series
por: McKenzie-Brown, Anne Marie, et al.
Publicado: (2023)

The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment
por: Rozpędek-Kamińska, Wioletta, et al.
Publicado: (2021)

Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses
por: Gay, Gabrielle, et al.
Publicado: (2016)

Low density neutrophils (LDN) in postoperative abdominal cavity assist the peritoneal recurrence through the production of neutrophil extracellular traps (NETs)
por: Kanamaru, Rihito, et al.
Publicado: (2018)

No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study
por: Raknes, Guttorm, et al.
Publicado: (2020)

Control of Bone Resorption by Semaphorin 4D Is Dependent on Ovarian Function
por: Dacquin, Romain, et al.
Publicado: (2011)

Chronic intermittent hypoxia, a hallmark of obstructive sleep apnea, promotes 4T1 breast cancer development through endothelin-1 receptors
por: Minoves, Mélanie, et al.
Publicado: (2022)

Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells
por: Kobayashi, Eiji, et al.
Publicado: (2019)

In vivo optical imaging of integrin α(V)-β(3 )in mice using multivalent or monovalent cRGD targeting vectors
por: Jin, Zhao-Hui, et al.
Publicado: (2007)

The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-kB signalling via EZH2
por: Braun, Laurence, et al.
Publicado: (2019)

Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation
por: de Frutos, Cristina A, et al.
Publicado: (2009)

Azanitrile Cathepsin K Inhibitors: Effects on Cell Toxicity, Osteoblast-Induced Mineralization and Osteoclast-Mediated Bone Resorption
por: Ren, Zhong-Yuan, et al.
Publicado: (2015)

Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells
por: Peronne, Lauralie, et al.
Publicado: (2020)

A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study
por: Raknes, Guttorm, et al.
Publicado: (2016)

UCH-L1 inhibitor LDN-57444 hampers mouse oocyte maturation by regulating oxidative stress and mitochondrial function and reducing ERK1/2 expression
por: Yuan, Pan, et al.
Publicado: (2020)

Low-dose naltrexone for the induction of remission in patients with mild to moderate Crohn’s disease: protocol for the randomised, double-blinded, placebo-controlled, multicentre LDN Crohn study
por: Paulides, Emma, et al.
Publicado: (2022)

Conversions between noise exposure metrics 24-hour Leq, Ldn, and Lden: the impact of diurnal local bus traffic patterns on population annoyance in the United States
por: Seto, Edmund, et al.
Publicado: (2023)

Cortinarius section Bicolores and section Saturnini (Basidiomycota, Agaricales), a morphogenetic overview of European and North American species
por: Liimatainen, K., et al.
Publicado: (2017)

Analgesic efficacy of ultrasound-guided interscalene block vs. supraclavicular block for ambulatory arthroscopic rotator cuff repair: A randomised noninferiority study
por: Cabaton, Julien, et al.
Publicado: (2019)

Bone Disease in Nephropathic Cystinosis: Beyond Renal Osteodystrophy
por: Machuca-Gayet, Irma, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gu19urf31nneao6mg3i0db5lev