Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

Myeloid-derived suppressor cells (MDSCs) play crucial roles in tumorigenesis and their inhibition is critical for successful cancer immunotherapy. MDSCs undergo metabolic reprogramming from glycolysis to fatty acid oxidation (FAO) and oxidative phosphorylation led by lipid accumulation in tumor. Inc...

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Detalles Bibliográficos
Autores principales: Yan, Dehong, Adeshakin, Adeleye O., Xu, Meichen, Afolabi, Lukman O., Zhang, Guizhong, Chen, Youhai H., Wan, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593140/
https://www.ncbi.nlm.nih.gov/pubmed/31275326
http://dx.doi.org/10.3389/fimmu.2019.01399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593140/
https://www.ncbi.nlm.nih.gov/pubmed/31275326
http://dx.doi.org/10.3389/fimmu.2019.01399

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