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Photoredox-Catalyzed Enantioselective α-Deuteration of Azaarenes with D(2)O

The site-specific incorporation of deuterium (D) into small molecules is frequently used to access isotopically labeled compounds with broad utility in many research areas, such as drug development, mechanistic studies, and NMR analyses. Nevertheless, the deuteration of a stereocenter in an enantios...

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Detalles Bibliográficos
Autores principales: Shao, Tianju, Li, Yajuan, Ma, Nana, Li, Chunyang, Chai, Guobi, Zhao, Xiaowei, Qiao, Baokun, Jiang, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593145/
https://www.ncbi.nlm.nih.gov/pubmed/31229890
http://dx.doi.org/10.1016/j.isci.2019.06.007