Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation

OBJECTIVE: Physiological mechanical loading reduces inflammatory signalling in numerous cell types including articular chondrocytes however the mechanism responsible remains unclear. This study investigates the role of chondrocyte primary cilia and associated intraflagellar transport (IFT) in the me...

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Detalles Bibliográficos
Autores principales: Fu, S., Thompson, C.L., Ali, A., Wang, W., Chapple, J.P., Mitchison, H.M., Beales, P.L., Wann, A.K.T., Knight, M.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593179/
https://www.ncbi.nlm.nih.gov/pubmed/30922983
http://dx.doi.org/10.1016/j.joca.2019.03.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593179/
https://www.ncbi.nlm.nih.gov/pubmed/30922983
http://dx.doi.org/10.1016/j.joca.2019.03.003

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