Fra-1 and c-Fos N-Terminal Deletion Mutants Impair Breast Tumor Cell Proliferation by Blocking Lipid Synthesis Activation

Tumor cells require high rates of lipid synthesis to support membrane biogenesis for their exacerbated growth. The only two proteins known that activate phospholipid synthesis are Fra-1 and c-Fos, two members of the AP-1 family of transcription factors. These proteins that are overexpressed in human...

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Detalles Bibliográficos
Autores principales: Racca, Ana Cristina, Prucca, César Germán, Caputto, Beatriz Leonor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593343/
https://www.ncbi.nlm.nih.gov/pubmed/31275861
http://dx.doi.org/10.3389/fonc.2019.00544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593343/
https://www.ncbi.nlm.nih.gov/pubmed/31275861
http://dx.doi.org/10.3389/fonc.2019.00544

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