Cargando…

Diosbulbin B-Induced Mitochondria-Dependent Apoptosis in L-02 Hepatocytes is Regulated by Reactive Oxygen Species-Mediated Autophagy

Aim: Diosbulbin B (DB) is a major diterpenoid compound found in Dioscorea bulbifera L, a traditional medicinal herb in China. Clinical reports have confirmed that Dioscorea bulbifera L. can induce significant hepatotoxicity. In this study, we showed that DB can induce mitochondria-dependent apoptosi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Jing, Xue, Mei, Liu, Yamin, Zhu, Sirui, Li, Yu, Liu, Xiaoli, Cai, Danhong, Rui, Jia, Zhang, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593359/ https://www.ncbi.nlm.nih.gov/pubmed/31275148 http://dx.doi.org/10.3389/fphar.2019.00676

Ejemplares similares

Methylprednisolone Decreases Mitochondria-Mediated Apoptosis and Autophagy Dysfunction in Hepatocytes of Experimental Autoimmune Hepatitis Model via the Akt/mTOR Signaling
por: Fan, Xiaoli, et al.
Publicado: (2019)

Chemical Identity of Interaction of Protein with Reactive Metabolite of Diosbulbin B In Vitro and In Vivo
por: Wang, Kai, et al.
Publicado: (2017)

8-Gingerol Ameliorates Myocardial Fibrosis by Attenuating Reactive Oxygen Species, Apoptosis, and Autophagy via the PI3K/Akt/mTOR Signaling Pathway
por: Xue, Yucong, et al.
Publicado: (2021)

Ethionine Suppresses Mitochondria Autophagy and Induces Apoptosis via Activation of Reactive Oxygen Species in Neural Tube Defects
por: Zhang, Li, et al.
Publicado: (2020)

Coordinated Contribution of NADPH Oxidase- and Mitochondria-Derived Reactive Oxygen Species in Metabolic Syndrome and Its Implication in Renal Dysfunction
por: Lee, Hewang, et al.
Publicado: (2021)

Generation of Reactive Oxygen Species by Mitochondria
por: Hernansanz-Agustín, Pablo, et al.
Publicado: (2021)

Drug-Drug Interaction Potential, Cytotoxicity, and Reactive Oxygen Species Production of Salix Cortex Extracts Using Human Hepatocyte-Like HepaRG Cells
por: Gomes, João Victor Dutra, et al.
Publicado: (2021)

Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis
por: Tian, Wei, et al.
Publicado: (2020)

The Role of Mitochondria-Derived Reactive Oxygen Species in Hyperthermia-Induced Platelet Apoptosis
por: Wang, Zhicheng, et al.
Publicado: (2013)

Mitochondria-Derived Reactive Oxygen Species Play an Important Role in Doxorubicin-Induced Platelet Apoptosis
por: Wang, Zhicheng, et al.
Publicado: (2015)

PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells
por: Zhao, Chunle, et al.
Publicado: (2019)

How mitochondria produce reactive oxygen species
por: Murphy, Michael P.
Publicado: (2008)

Mitochondria and Reactive Oxygen Species: Physiology and Pathophysiology
por: Bolisetty, Subhashini, et al.
Publicado: (2013)

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis
por: Su, Lian-Jiu, et al.
Publicado: (2019)

Hydrogen Sulfide Attenuates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway
por: Wu, Dongdong, et al.
Publicado: (2020)

Reactive Oxygen Species in Cardiovascular Calcification: Role of Medicinal Plants
por: Qiao, Yu
Publicado: (2022)

Synthesis of Chalcone Derivatives: Inducing Apoptosis of HepG2 Cells via Regulating Reactive Oxygen Species and Mitochondrial Pathway
por: Zhu, Hongtian, et al.
Publicado: (2019)

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria
por: Nakamura, Seiji, et al.
Publicado: (2009)

A Frog Peptide Ameliorates Skin Photoaging Through Scavenging Reactive Oxygen Species
por: Feng, Guizhu, et al.
Publicado: (2022)

Anticancer therapeutic effect of ginsenosides through mediating reactive oxygen species
por: Li, Xiaonan, et al.
Publicado: (2023)

Roles of Reactive Oxygen Species and Mitochondria in Seed Germination
por: Farooq, Muhammad Awais, et al.
Publicado: (2021)

Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis
por: Lim, Chuan Bian, et al.
Publicado: (2015)

Fhit–Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells
por: Druck, Teresa, et al.
Publicado: (2019)

ATM at the crossroads of reactive oxygen species and autophagy
por: Xie, Xiaochen, et al.
Publicado: (2021)

ASPP2 Coordinates ERS-Mediated Autophagy and Apoptosis Through mTORC1 Pathway in Hepatocyte Injury Induced by TNF-α
por: Yao, Jia, et al.
Publicado: (2022)

Pardaxin Activates Excessive Mitophagy and Mitochondria-Mediated Apoptosis in Human Ovarian Cancer by Inducing Reactive Oxygen Species
por: Chen, Yen-Po, et al.
Publicado: (2021)

Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect
por: Sithara, Thomas, et al.
Publicado: (2017)

Computational Models of Reactive Oxygen Species as Metabolic Byproducts and Signal-Transduction Modulators
por: Pereira, Elizabeth J., et al.
Publicado: (2016)

Navigating Calcium and Reactive Oxygen Species by Natural Flavones for the Treatment of Heart Failure
por: Yu, Tianhao, et al.
Publicado: (2021)

Angelica sinensis polysaccharide (ASP) attenuates diosbulbin-B (DB)-induced hepatotoxicity through activating the MEK/ERK pathway
por: Li, Chunfeng, et al.
Publicado: (2021)

Exendin-4 Protects Mitochondria from Reactive Oxygen Species Induced Apoptosis in Pancreatic Beta Cells
por: Li, Zhen, et al.
Publicado: (2013)

EM23, A Natural Sesquiterpene Lactone from Elephantopus mollis, Induces Apoptosis in Human Myeloid Leukemia Cells through Thioredoxin- and Reactive Oxygen Species-Mediated Signaling Pathways
por: Li, Hongyu, et al.
Publicado: (2016)

Insight Into the Molecular Dynamic Simulation Studies of Reactive Oxygen Species in Native Skin Membrane
por: Yadav, Dharmendra K., et al.
Publicado: (2018)

Pimozide Inhibits the Human Prostate Cancer Cells Through the Generation of Reactive Oxygen Species
por: Kim, Ukjin, et al.
Publicado: (2020)

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis
por: Dan Dunn, Joe, et al.
Publicado: (2015)

Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers
por: Xu, Hong-Gui, et al.
Publicado: (2021)

Transferred mitochondria accumulate reactive oxygen species, promoting proliferation
por: Kidwell, Chelsea U, et al.
Publicado: (2023)

Microcystin-LR Induced Reactive Oxygen Species Mediate Cytoskeletal Disruption and Apoptosis of Hepatocytes in Cyprinus carpio L.
por: Jiang, Jinlin, et al.
Publicado: (2013)

Honokiol Ameliorates Post-Myocardial Infarction Heart Failure Through Ucp3-Mediated Reactive Oxygen Species Inhibition
por: Liu, Jianyu, et al.
Publicado: (2022)

Downregulation of Reactive Oxygen Species in Apoptosis
por: Jeong, Chul-Ho, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_d5h7of4rc0jocpgmdjfes5gf95