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On estimating evolutionary probabilities of population variants

BACKGROUND: The evolutionary probability (EP) of an allele in a DNA or protein sequence predicts evolutionarily permissible (ePerm; EP ≥ 0.05) and forbidden (eForb; EP < 0.05) variants. EP of an allele represents an independent evolutionary expectation of observing an allele in a population based...

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Detalles Bibliográficos
Autores principales: Patel, Ravi, Kumar, Sudhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593550/
https://www.ncbi.nlm.nih.gov/pubmed/31238981
http://dx.doi.org/10.1186/s12862-019-1455-7